The American National Insurance Company (ANICO) constructed the structure for the expansion of their offices.
The architect of the structure was Andrew Fraser. Born in Inverness, Scotland, Fraser received his degree from Edinburgh University and immigrated to the United States around 1915. Fraser moved to Galveston in 1926 and designed three significant buildings constructed in Galveston in the 1920s: the Jean Lafitte Hotel, the Medical Arts Building, and the Buccaneer Hotel (demolished).
Fraser described the Medical Arts Building's architectural style as sometimes termed new American Gothic, or American Gothic perpendicular.